Government astronauts undertake approximately 18 months of basic training to prepare themselves for spaceflight. Mission specific training takes a further 12-18 months once a mission is assigned. Commercial spaceflight participants will require far less preparation, however training and preparation will be needed and will range from a few days for suborbital participants, to potentially several months for orbital ‘space tourists’ who have the resources to participate in extra vehicle activity (for leisure purposes). The wide range of space vehicles currently in production and the variety of spaceflight opportunity packages, with their associated procedures, are such that there will be no simple prescription for spaceflight preparation in the first few years of commercial human spaceflight. It is clear, however, that appropriate standards will be required which outline the minimal duration and appropriate nature of the preparatory measures necessary to adequately prepare the general public for travel to and spend time in space. Additionally, commercial spaceflight professionals such as space pilots and in due course orbital engineers and scientists, will require training to a far greater standard than space tourists, but far less rigorous and current government astronauts. To further complicate the issue, members of the general public travelling into space will of course exhibit a wide variety of medical conditions and fitness levels, many of which can be impacted by travel to and exposure to space. Preparing one individual for a given spaceflight might require 2 weeks in one instance, but potentially 2 months for someone else if their condition is more likely to be negatively impacted by the experience. There is a need , therefore, to understand what literature and research findings exist that can support the identification and recommendation of the minimal space training/preparation standards that should be employed for commercial spaceflight participant safety, as the embryonic commercial human spaceflight sector becomes a reality. I would propose that a systematic review be conducted on the topic of ‘spaceflight training and preparation for commercial participants’. Please note that this proposal refers to training and preparing people for spaceflight, and not the precursory medical/psychological clearance for space flight.